Validating refinements to laboratory animal housing 100 free sex date toronto

Those questions are outlined in Box 5-1 and elaborated below.Toxicity-Pathway Identification—What are the key pathways whose perturbations result in toxicity?The categories of toxicity tests and methods to be developed are outlined below, and the primary questions to be answered in their development are presented in Box 5-2.Methods to Predict Metabolism—How can adequate testing for metabolites in the high-throughput assays be ensured?

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Life Stages—How can the perturbations of toxicity pathways associated with developmental timing or aging be best captured to enable the advancement of high-throughput assays?Accordingly, the committee has proposed development of a testing structure that evaluates perturbations in toxicity pathways and relies on a mix of high-and medium-throughput assays and targeted in vivo tests as the foundation of its vision for toxicity testing.This chapter discusses the kinds of applied and basic research needed to support the new toxicity-testing approach, the institutional resources required to support and encourage it, and the valuable products that can be expected during the transition from the current apical end-point testing to a mechanistically based in vivo and in vitro test system.The time for full realization of the new test strategy, with its mix of in vitro and in vivo test batteries that can rapidly and inexpensively assess large numbers of substances with adequate coverage of possible end points, could be 20 or more years.This chapter starts by discussing basic research that will provide the foundation for assay development.

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